SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Mitchell Braxton D.)
 

Search: WFRF:(Mitchell Braxton D.) > Kuusisto Johanna > Discovery and refin...

Discovery and refinement of loci associated with lipid levels

Willer, Cristen J. (author)
Schmidt, Ellen M. (author)
Sengupta, Sebanti (author)
show more...
Peloso, Gina M. (author)
Gustafsson, Stefan (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Kanoni, Stavroula (author)
Ganna, Andrea (author)
Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Chen, Jin (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Mora, Samia (author)
Beckmann, Jacques S. (author)
Bragg-Gresham, Jennifer L. (author)
Chang, Hsing-Yi (author)
Demirkan, Ayse (author)
Den Hertog, Heleen M. (author)
Do, Ron (author)
Donnelly, Louise A. (author)
Ehret, Georg B. (author)
Esko, Tonu (author)
Feitosa, Mary F. (author)
Ferreira, Teresa (author)
Fischer, Krista (author)
Fontanillas, Pierre (author)
Fraser, Ross M. (author)
Freitag, Daniel F. (author)
Gurdasani, Deepti (author)
Heikkila, Kauko (author)
Hyppoenen, Elina (author)
Isaacs, Aaron (author)
Jackson, Anne U. (author)
Johansson, Åsa (author)
Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)
Johnson, Toby (author)
Kaakinen, Marika (author)
Kettunen, Johannes (author)
Kleber, Marcus E. (author)
Li, Xiaohui (author)
Luan, Jian'an (author)
Lyytikainen, Leo-Pekka (author)
Magnusson, Patrik K. E. (author)
Karolinska Institutet
Mangino, Massimo (author)
Mihailov, Evelin (author)
Montasser, May E. (author)
Mueller-Nurasyid, Martina (author)
Nolte, Ilja M. (author)
O'Connell, Jeffrey R. (author)
Palmer, Cameron D. (author)
Perola, Markus (author)
Petersen, Ann-Kristin (author)
Sanna, Serena (author)
Saxena, Richa (author)
Service, Susan K. (author)
Shah, Sonia (author)
Shungin, Dmitry (author)
Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi
Sidore, Carlo (author)
Song, Ci (author)
Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Strawbridge, Rona J. (author)
Karolinska Institutet
Surakka, Ida (author)
Tanaka, Toshiko (author)
Teslovich, Tanya M. (author)
Thorleifsson, Gudmar (author)
Van den Herik, Evita G. (author)
Voight, Benjamin F. (author)
Volcik, Kelly A. (author)
Waite, Lindsay L. (author)
Wong, Andrew (author)
Wu, Ying (author)
Zhang, Weihua (author)
Absher, Devin (author)
Asiki, Gershim (author)
Barroso, Ines (author)
Been, Latonya F. (author)
Bolton, Jennifer L. (author)
Bonnycastle, Lori L. (author)
Brambilla, Paolo (author)
Burnett, Mary S. (author)
Cesana, Giancarlo (author)
Dimitriou, Maria (author)
Doney, Alex S. F. (author)
Doering, Angela (author)
Elliott, Paul (author)
Epstein, Stephen E. (author)
Eyjolfsson, Gudmundur Ingi (author)
Gigante, Bruna (author)
Karolinska Institutet
Goodarzi, Mark O. (author)
Grallert, Harald (author)
Gravito, Martha L. (author)
Groves, Christopher J. (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Hartikainen, Anna-Liisa (author)
Hayward, Caroline (author)
Hernandez, Dena (author)
Hicks, Andrew A. (author)
Holm, Hilma (author)
Hung, Yi-Jen (author)
Illig, Thomas (author)
Jones, Michelle R. (author)
Kaleebu, Pontiano (author)
Kastelein, John J. P. (author)
Khaw, Kay-Tee (author)
Kim, Eric (author)
Klopp, Norman (author)
Komulainen, Pirjo (author)
Kumari, Meena (author)
Langenberg, Claudia (author)
Lehtimaki, Terho (author)
Lin, Shih-Yi (author)
Lindstrom, Jaana (author)
Loos, Ruth J. F. (author)
Mach, Francois (author)
McArdle, Wendy L. (author)
Meisinger, Christa (author)
Mitchell, Braxton D. (author)
Mueller, Gabrielle (author)
Nagaraja, Ramaiah (author)
Narisu, Narisu (author)
Karolinska Institutet
Nieminen, Tuomo V. M. (author)
Nsubuga, Rebecca N. (author)
Olafsson, Isleifur (author)
Ong, Ken K. (author)
Palotie, Aarno (author)
Papamarkou, Theodore (author)
Pomilla, Cristina (author)
Pouta, Anneli (author)
Rader, Daniel J. (author)
Reilly, Muredach P. (author)
Ridker, Paul M. (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Ruokonen, Aimo (author)
Samani, Nilesh (author)
Scharnagl, Hubert (author)
Seeley, Janet (author)
Silander, Kaisa (author)
Stancakova, Alena (author)
Stirrups, Kathleen (author)
Swift, Amy J. (author)
Tiret, Laurence (author)
Uitterlinden, Andre G. (author)
van Pelt, L. Joost (author)
Vedantam, Sailaja (author)
Wainwright, Nicholas (author)
Wijmenga, Cisca (author)
Wild, Sarah H. (author)
Willemsen, Gonneke (author)
Wilsgaard, Tom (author)
Wilson, James F. (author)
Young, Elizabeth H. (author)
Zhao, Jing Hua (author)
Adair, Linda S. (author)
Arveiler, Dominique (author)
Assimes, Themistocles L. (author)
Bandinelli, Stefania (author)
Bennett, Franklyn (author)
Bochud, Murielle (author)
Boehm, Bernhard O. (author)
Boomsma, Dorret I. (author)
Borecki, Ingrid B. (author)
Bornstein, Stefan R. (author)
Bovet, Pascal (author)
Burnier, Michel (author)
Campbell, Harry (author)
Chakravarti, Aravinda (author)
Chambers, John C. (author)
Chen, Yii-Der Ida (author)
Collins, Francis S. (author)
Cooper, Richard S. (author)
Danesh, John (author)
Dedoussis, George (author)
de Faire, Ulf (author)
Karolinska Institutet
Feranil, Alan B. (author)
Ferrieres, Jean (author)
Ferrucci, Luigi (author)
Freimer, Nelson B. (author)
Gieger, Christian (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Gudnason, Vilmundur (author)
Gyllensten, Ulf (author)
Uppsala universitet,Genomik
Hamsten, Anders (author)
Karolinska Institutet
Harris, Tamara B. (author)
Hingorani, Aroon (author)
Hirschhorn, Joel N. (author)
Hofman, Albert (author)
Hovingh, G. Kees (author)
Hsiung, Chao Agnes (author)
Humphries, Steve E. (author)
Hunt, Steven C. (author)
Hveem, Kristian (author)
Iribarren, Carlos (author)
Jarvelin, Marjo-Riitta (author)
Jula, Antti (author)
Kahonen, Mika (author)
Kaprio, Jaakko (author)
Kesaniemi, Antero (author)
Kivimaki, Mika (author)
Kooner, Jaspal S. (author)
Koudstaal, Peter J. (author)
Krauss, Ronald M. (author)
Kuh, Diana (author)
Kuusisto, Johanna (author)
Kyvik, Kirsten O. (author)
Laakso, Markku (author)
Lakka, Timo A. (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Lindgren, Cecilia M. (author)
Martin, Nicholas G. (author)
Maerz, Winfried (author)
McCarthy, Mark I. (author)
McKenzie, Colin A. (author)
Meneton, Pierre (author)
Metspalu, Andres (author)
Moilanen, Leena (author)
Morris, Andrew D. (author)
Munroe, Patricia B. (author)
Njolstad, Inger (author)
Pedersen, Nancy L. (author)
Power, Chris (author)
Pramstaller, Peter P. (author)
Price, Jackie F. (author)
Psaty, Bruce M. (author)
Quertermous, Thomas (author)
Rauramaa, Rainer (author)
Saleheen, Danish (author)
Salomaa, Veikko (author)
Sanghera, Dharambir K. (author)
Saramies, Jouko (author)
Schwarz, Peter E. H. (author)
Sheu, Wayne H-H (author)
Shuldiner, Alan R. (author)
Siegbahn, Agneta (author)
Uppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation och inflammationsvetenskap
Spector, Tim D. (author)
Stefansson, Kari (author)
Strachan, David P. (author)
Tayo, Bamidele O. (author)
Tremoli, Elena (author)
Tuomilehto, Jaakko (author)
Uusitupa, Matti (author)
van Duijn, Cornelia M. (author)
Vollenweider, Peter (author)
Wallentin, Lars (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
Wareham, Nicholas J. (author)
Whitfield, John B. (author)
Wolffenbuttel, Bruce H. R. (author)
Ordovas, Jose M. (author)
Boerwinkle, Eric (author)
Palmer, Colin N. A. (author)
Thorsteinsdottir, Unnur (author)
Chasman, Daniel I. (author)
Rotter, Jerome I. (author)
Franks, Paul (author)
Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Lunds universitet, Harvard University
Ripatti, Samuli (author)
Cupples, L. Adrienne (author)
Sandhu, Manjinder S. (author)
Rich, Stephen S. (author)
Boehnke, Michael (author)
Deloukas, Panos (author)
Kathiresan, Sekar (author)
Mohlke, Karen L. (author)
Ingelsson, Erik (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Abecasis, Goncalo R. (author)
show less...
 (creator_code:org_t)
2013-10-06
2013
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Find more in SwePub

By the author/editor
Willer, Cristen ...
Schmidt, Ellen M ...
Sengupta, Sebant ...
Peloso, Gina M.
Gustafsson, Stef ...
Kanoni, Stavroul ...
show more...
Ganna, Andrea
Chen, Jin
Lind, Lars
Mora, Samia
Beckmann, Jacque ...
Bragg-Gresham, J ...
Chang, Hsing-Yi
Demirkan, Ayse
Den Hertog, Hele ...
Do, Ron
Donnelly, Louise ...
Ehret, Georg B.
Esko, Tonu
Feitosa, Mary F.
Ferreira, Teresa
Fischer, Krista
Fontanillas, Pie ...
Fraser, Ross M.
Freitag, Daniel ...
Gurdasani, Deept ...
Heikkila, Kauko
Hyppoenen, Elina
Isaacs, Aaron
Jackson, Anne U.
Johansson, Åsa
Johnson, Toby
Kaakinen, Marika
Kettunen, Johann ...
Kleber, Marcus E ...
Li, Xiaohui
Luan, Jian'an
Lyytikainen, Leo ...
Magnusson, Patri ...
Mangino, Massimo
Mihailov, Evelin
Montasser, May E ...
Mueller-Nurasyid ...
Nolte, Ilja M.
O'Connell, Jeffr ...
Palmer, Cameron ...
Perola, Markus
Petersen, Ann-Kr ...
Sanna, Serena
Saxena, Richa
Service, Susan K ...
Shah, Sonia
Shungin, Dmitry
Sidore, Carlo
Song, Ci
Strawbridge, Ron ...
Surakka, Ida
Tanaka, Toshiko
Teslovich, Tanya ...
Thorleifsson, Gu ...
Van den Herik, E ...
Voight, Benjamin ...
Volcik, Kelly A.
Waite, Lindsay L ...
Wong, Andrew
Wu, Ying
Zhang, Weihua
Absher, Devin
Asiki, Gershim
Barroso, Ines
Been, Latonya F.
Bolton, Jennifer ...
Bonnycastle, Lor ...
Brambilla, Paolo
Burnett, Mary S.
Cesana, Giancarl ...
Dimitriou, Maria
Doney, Alex S. F ...
Doering, Angela
Elliott, Paul
Epstein, Stephen ...
Eyjolfsson, Gudm ...
Gigante, Bruna
Goodarzi, Mark O ...
Grallert, Harald
Gravito, Martha ...
Groves, Christop ...
Hallmans, Göran
Hartikainen, Ann ...
Hayward, Carolin ...
Hernandez, Dena
Hicks, Andrew A.
Holm, Hilma
Hung, Yi-Jen
Illig, Thomas
Jones, Michelle ...
Kaleebu, Pontian ...
Kastelein, John ...
Khaw, Kay-Tee
Kim, Eric
Klopp, Norman
Komulainen, Pirj ...
Kumari, Meena
Langenberg, Clau ...
Lehtimaki, Terho
Lin, Shih-Yi
Lindstrom, Jaana
Loos, Ruth J. F.
Mach, Francois
McArdle, Wendy L ...
Meisinger, Chris ...
Mitchell, Braxto ...
Mueller, Gabriel ...
Nagaraja, Ramaia ...
Narisu, Narisu
Nieminen, Tuomo ...
Nsubuga, Rebecca ...
Olafsson, Isleif ...
Ong, Ken K.
Palotie, Aarno
Papamarkou, Theo ...
Pomilla, Cristin ...
Pouta, Anneli
Rader, Daniel J.
Reilly, Muredach ...
Ridker, Paul M.
Rivadeneira, Fer ...
Rudan, Igor
Ruokonen, Aimo
Samani, Nilesh
Scharnagl, Huber ...
Seeley, Janet
Silander, Kaisa
Stancakova, Alen ...
Stirrups, Kathle ...
Swift, Amy J.
Tiret, Laurence
Uitterlinden, An ...
van Pelt, L. Joo ...
Vedantam, Sailaj ...
Wainwright, Nich ...
Wijmenga, Cisca
Wild, Sarah H.
Willemsen, Gonne ...
Wilsgaard, Tom
Wilson, James F.
Young, Elizabeth ...
Zhao, Jing Hua
Adair, Linda S.
Arveiler, Domini ...
Assimes, Themist ...
Bandinelli, Stef ...
Bennett, Frankly ...
Bochud, Murielle
Boehm, Bernhard ...
Boomsma, Dorret ...
Borecki, Ingrid ...
Bornstein, Stefa ...
Bovet, Pascal
Burnier, Michel
Campbell, Harry
Chakravarti, Ara ...
Chambers, John C ...
Chen, Yii-Der Id ...
Collins, Francis ...
Cooper, Richard ...
Danesh, John
Dedoussis, Georg ...
de Faire, Ulf
Feranil, Alan B.
Ferrieres, Jean
Ferrucci, Luigi
Freimer, Nelson ...
Gieger, Christia ...
Groop, Leif
Gudnason, Vilmun ...
Gyllensten, Ulf
Hamsten, Anders
Harris, Tamara B ...
Hingorani, Aroon
Hirschhorn, Joel ...
Hofman, Albert
Hovingh, G. Kees
Hsiung, Chao Agn ...
Humphries, Steve ...
Hunt, Steven C.
Hveem, Kristian
Iribarren, Carlo ...
Jarvelin, Marjo- ...
Jula, Antti
Kahonen, Mika
Kaprio, Jaakko
Kesaniemi, Anter ...
Kivimaki, Mika
Kooner, Jaspal S ...
Koudstaal, Peter ...
Krauss, Ronald M ...
Kuh, Diana
Kuusisto, Johann ...
Kyvik, Kirsten O ...
Laakso, Markku
Lakka, Timo A.
Lindgren, Cecili ...
Martin, Nicholas ...
Maerz, Winfried
McCarthy, Mark I ...
McKenzie, Colin ...
Meneton, Pierre
Metspalu, Andres
Moilanen, Leena
Morris, Andrew D ...
Munroe, Patricia ...
Njolstad, Inger
Pedersen, Nancy ...
Power, Chris
Pramstaller, Pet ...
Price, Jackie F.
Psaty, Bruce M.
Quertermous, Tho ...
Rauramaa, Rainer
Saleheen, Danish
Salomaa, Veikko
Sanghera, Dharam ...
Saramies, Jouko
Schwarz, Peter E ...
Sheu, Wayne H-H
Shuldiner, Alan ...
Siegbahn, Agneta
Spector, Tim D.
Stefansson, Kari
Strachan, David ...
Tayo, Bamidele O ...
Tremoli, Elena
Tuomilehto, Jaak ...
Uusitupa, Matti
van Duijn, Corne ...
Vollenweider, Pe ...
Wallentin, Lars
Wareham, Nichola ...
Whitfield, John ...
Wolffenbuttel, B ...
Ordovas, Jose M.
Boerwinkle, Eric
Palmer, Colin N. ...
Thorsteinsdottir ...
Chasman, Daniel ...
Rotter, Jerome I ...
Franks, Paul
Ripatti, Samuli
Cupples, L. Adri ...
Sandhu, Manjinde ...
Rich, Stephen S.
Boehnke, Michael
Deloukas, Panos
Kathiresan, Seka ...
Mohlke, Karen L.
Ingelsson, Erik
Abecasis, Goncal ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Genetics
By the university
Uppsala University
Lund University
Karolinska Institutet
Umeå University

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view